Frequently Asked Questions | LUMRYZ™ (sodium oxybate)

Find answers to frequently asked questions about LUMRYZ

How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways:

Immediate-release granules start working as you fall asleep
Controlled-release granules start working later in place of waking for a second dose

Learn more about LUMRYZ

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

See more results from the trial

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

Learn how LUMRYZ is different

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions for Use for how to prepare, shake, and take LUMRYZ.

Find more details and watch our step-by-step guide

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

Download Doctor Discussion Guide

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ Risk Evaluation and Mitigation Strategy (REMS) and RYZUP™ Support Services. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Find helpful forms and learn more about enrolling in RYZUP

What is the taste and texture of LUMRYZ?

Because of the mixed-release granules that make up the extended-release formula for LUMRYZ, your dose will have a gritty texture and salty taste. Some granules may stick together and look milky and lumpy even after being thoroughly shaken in the provided mixing cup.

See the Instructions for Use for more on what to expect when taking LUMRYZ.

What are the most common side effects?

The most common side effects reported by participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

Learn more about side effects

Are any financial assistance programs available?

Yes, RYZUP Support Services offers financial support programs for eligible patients, including co-pay assistance for commercially insured patients. Eligible patients may pay as little as $0 co-pay per month.*

See how RYZUP Support Services can help

Important Safety Information

WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

Do not take LUMRYZ if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself. Call your doctor right away if you or your child have symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you or your child start sleepwalking.

Tell your doctor if you or your child are on a salt-restricted diet or have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.

LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Find answers to frequently asked questions about LUMRYZ

INDICATIONS

Important Safety Information

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