How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways: • Immediate-release granules start working as you fall asleep • Controlled-release granules start working later in place of waking for a second dose

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions For Use on how to prepare, shake, and take LUMRYZ.

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ REMS and RYZUP™. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Are any financial assistance programs available?

Yes, RYZUP Support Services are dedicated to helping you throughout your treatment journey, including financial assistance services such as co-pays as little as $0 if you’re eligible.*

What are the most common side effects?

The most common side effects reported by participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

Starting LUMRYZ™ (sodium oxybate)

Ready to switch or start on once-at-bedtime LUMRYZ?

For adults: Once you and your healthcare provider have decided that LUMRYZ is right for you, your healthcare provider will work with you to consider the best way to start treatment*

Switching to LUMRYZ

If you ARE currently taking a sodium oxybate:
Your healthcare provider can switch you to LUMRYZ at the closest dose—equal to the amount of medicine you’re taking now.

Starting with LUMRYZ

If you ARE NOT currently taking a sodium oxybate:
Your healthcare provider will start you on the lowest dose of LUMRYZ and increase your dose gradually over time until you reach the dose that’s right for you.

*For pediatric dosing, please see the full Prescribing Information.

It may take time before noticing a difference with LUMRYZ

In the clinical trial, some participants saw improvement in their symptoms by week 3 on a 6-g dose, while others saw improvement at week 13 after increasing to the 9-g dose.^†

^†The LUMRYZ double-blind, placebo-controlled clinical trial included participants with narcolepsy treated with LUMRYZ (n=107). The results measured at week 3 (n=88), week 8 (n=77), and week 13 (n=69) showed daytime symptom improvement of participants on the 6-g, 7.5-g, and 9-g doses of LUMRYZ, respectively. Individual results may vary.

Premeasured packets contain your prescribed dose each time

Each dosage strength comes in a
different-color packet.

See how LUMRYZ helped treat the daytime symptoms of narcolepsy for these individuals.

Watch now

“I like the dosing packets for LUMRYZ because I don’t have to measure it myself. It allows me to just focus on mixing the medicine and not have to guess or stress that I got the right amount.”

– Tyler F., living with narcolepsy and treating with LUMRYZ

Tyler was compensated by Avadel Pharmaceuticals for his time. Individual results may vary.

How does LUMRYZ fit into your bedtime routine?

LUMRYZ should be taken at least 2 hours after eating to help the medicine absorb into the bloodstream and should be the last thing you do before going to bed

Each premeasured packet contains your full prescribed dose:

Illustration of person pouring medicine into mixing cup with water inside

PREPARE

at your bedside by pouring water, then adding 1 premeasured packet into the provided mixing cup. Do not use hot water.

Illustration of person shaking LUMRYZ, timer on left indicating 60 seconds

SHAKE

for at least 60 seconds (1 minute).

TAKE

your medicine and lie in bed as you may fall asleep quickly.^‡

Make sure to take all the medicine in the mixing cup. After, add more water to the mixing cup and shake well again for 10 seconds, then take what remains of the mixture.

Because of this extended-release formulation, LUMRYZ does not fully dissolve in water and will have a gritty texture even after being shaken thoroughly in the mixing cup.

^‡Avoid getting out of your bed after taking LUMRYZ. Some people fall asleep within 5 minutes of taking LUMRYZ and most will fall asleep within 15 minutes. The time it takes you to fall asleep might be different from night to night.

These instructions are not complete. Please see Instructions for Use for complete administration directions.

Watch this step-by-step guide on how to take LUMRYZ:

Once-at-bedtime LUMRYZ offers you:

Demonstrated effectiveness

LUMRYZ delivered daytime symptom improvement in a clinical trial.

Premeasured single-dose packets

No second dose waiting on your nightstand to take in the middle of the night.

Discreet and convenient travel

Pack the number of dose packets you will need for your trip.

To learn more about LUMRYZ, download a copy of the LUMRYZ Digital Brochure.

Download

Learn about the process of getting started on LUMRYZ with RYZUP Support Services.

Visit RYZUP Support Services

INDICATIONS

LUMRYZ (sodium oxybate) for extended-release oral suspension is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.

sudden onset of weak or paralyzed muscles (cataplexy)

excessive daytime sleepiness (EDS)

Important Safety Information

WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

Do not take LUMRYZ if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself. Call your doctor right away if you or your child have symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you or your child start sleepwalking.

Tell your doctor if you or your child are on a salt-restricted diet or have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.

LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Ready to switch or start on once-at-bedtime LUMRYZ?

For adults: Once you and your healthcare provider have decided that LUMRYZ is right for you, your healthcare provider will work with you to consider the best way to start treatment*

Switching to LUMRYZ

Starting with LUMRYZ

It may take time before noticing a difference with LUMRYZ

Premeasured packets contain your prescribed dose each time

“I like the dosing packets for LUMRYZ because I don’t have to measure it myself. It allows me to just focus on mixing the medicine and not have to guess or stress that I got the right amount.”

How does LUMRYZ fit into your bedtime routine?

LUMRYZ should be taken at least 2 hours after eating to help the medicine absorb into the bloodstream and should be the last thing you do before going to bed

Each premeasured packet contains your full prescribed dose:

PREPARE

SHAKE

TAKE

Watch this step-by-step guide on how to take LUMRYZ:

Once-at-bedtime LUMRYZ offers you:

Demonstrated effectiveness

Premeasured single-dose packets

Discreet and convenient travel

Learn about the process of getting started on LUMRYZ with RYZUP Support Services.

INDICATIONS

INDICATIONS

Important Safety Information

The contents of this website are intended for patients.

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